Storage and handling of lyophilised peptides in the laboratory
Updated: October 8, 2026
A lyophilised peptide is a dry powder obtained by sublimating the water. In that state it is far more stable than in solution, but it remains sensitive to moisture, light and heat.
Temperature and light
For long-term storage −20 °C or below is recommended, dry and protected from light. Lyophilised peptides generally tolerate short periods at room temperature, such as transport, but should be refrigerated or frozen on receipt.
Moisture
- Many peptides are hygroscopic: they absorb water from the air and degrade sooner.
- Let the closed vial reach room temperature before opening it, to avoid condensation.
- Keep the vial open as briefly as possible and store it with desiccant.
Sensitive sequences
Methionine, cysteine and tryptophan residues oxidise easily; asparagine and glutamine can deamidate. These reactions are faster in solution than in powder, which is why repeated freeze–thaw cycles are avoided.
Records and safety
- Record the batch, receipt date and opening date of each vial.
- Check the safety data sheet and use the usual laboratory protective equipment.
- Do not ingest or administer. The material is for research use only.